Natural elastomeric fibres play central structural and functional roles in a variety of tissues
produced by many organisms from diverse Phyla. Most of these fibres feature amorphous …

Coiled coils are important nanomechanical building blocks in biological and biomimetic
materials. A mechanistic molecular understanding of their structural response to mechanical …

We have studied in silico the effect of proline, a model cosolvent, on local and global friction
coefficients in (un) folding of several typical alanine-based α-helical peptides. Local friction …

The eukaryotic DNA replication fork is a hub of enzymes that continuously act to synthesize
DNA, propagate DNA methylation and other epigenetic marks, perform quality control, repair …

The advent of atomic force microscopy, along with optical tweezers, ushered in a new field of
single molecule force spectroscopy, wherein the response of a single protein or a …

The nanomechanical response of a folded single protein, the natural nanomachine
responsible for myriad biological processes, provides insight into its function. The …

In single‐molecule force spectroscopy (SMFS), many studies have focused on the elasticity
and conformation of polymer chains, but little attention has been devoted to the dynamic …

Myosins are molecular motors that convert chemical energy into mechanical work.
Allosterically coupling ATP-binding, hydrolysis, and binding/dissociation to actin filaments …

In this paper we derive analytically from molecular dynamics (MD) simulations the friction
coefficients related to conformational transitions within several model peptides with α-helical …

Coiled-coils are filamentous proteins that form the basic building block of important force-
bearing cellular elements, such as intermediate filaments and myosin motors. In addition to …