Bacterial inclusion bodies: discovering their better half

U Rinas, E Garcia-Fruitós, JL Corchero… - Trends in biochemical …, 2017 - cell.com
Bacterial inclusion bodies (IBs) are functional, non-toxic amyloids occurring in recombinant
bacteria showing analogies with secretory granules of the mammalian endocrine system …

Bacterial inclusion bodies are industrially exploitable amyloids

A De Marco, N Ferrer-Miralles… - FEMS microbiology …, 2019 - academic.oup.com
Understanding the structure, functionalities and biology of functional amyloids is an issue of
emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria …

[HTML][HTML] Protein scaffolds in human clinics

O Cano-Garrido, N Serna, U Unzueta, E Parladé… - Biotechnology …, 2022 - Elsevier
Fundamental clinical areas such as drug delivery and regenerative medicine require
biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers …

Engineering secretory amyloids for remote and highly selective destruction of metastatic foci

MV Céspedes, O Cano‐Garrido, P Álamo… - Advanced …, 2020 - Wiley Online Library
Functional amyloids produced in bacteria as nanoscale inclusion bodies are intriguing but
poorly explored protein materials with wide therapeutic potential. Since they release …

Targeting antitumoral proteins to breast cancer by local administration of functional inclusion bodies

M Pesarrodona, T Jauset, ZV Díaz‐Riascos… - Advanced …, 2019 - Wiley Online Library
Two structurally and functionally unrelated proteins, namely Omomyc and p31, are
engineered as CD44‐targeted inclusion bodies produced in recombinant bacteria. In this …

Functional inclusion bodies produced in the yeast Pichia pastoris

F Rueda, B Gasser, A Sánchez-Chardi, M Roldán… - Microbial cell …, 2016 - Springer
Abstract Background Bacterial inclusion bodies (IBs) are non-toxic protein aggregates
commonly produced in recombinant bacteria. They are formed by a mixture of highly stable …

The biological potential hidden in inclusion bodies

L Gifre-Renom, J Seras-Franzoso, D Rafael, F Andrade… - Pharmaceutics, 2020 - mdpi.com
Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein
production processes, and several studies have demonstrated their potential as biomaterials …

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs

MV Céspedes, Y Fernández, U Unzueta, R Mendoza… - Scientific reports, 2016 - nature.com
In the human endocrine system many protein hormones including urotensin, glucagon,
obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory …

Potential of MMP-9 based nanoparticles at optimizing the cow dry period: Pulling apart the effects of MMP-9 and nanoparticles

L Gifre-Renom, JV Carratalá, S Parés… - Scientific reports, 2020 - nature.com
The cow dry period is a non-milking interval where the mammary gland involutes and
regenerates to guarantee an optimal milk production in the subsequent lactation. Important …

Engineering tumor cell targeting in nanoscale amyloidal materials

U Unzueta, J Seras-Franzoso, MV Céspedes… - …, 2016 - iopscience.iop.org
Bacterial inclusion bodies are non-toxic, mechanically stable and functional protein
amyloids within the nanoscale size range that are able to naturally penetrate into …