Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

Animal experimentation is widely used around the world for the identification of the root
causes of various diseases in humans and animals and for exploring treatment options …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Worldwide, the zebrafish has become a popular model for biomedical research and (eco)
toxicology. Particularly the use of embryos is receiving increasing attention, since they are …

Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological
disciplines. Substantial information gathered from developmental and genetic research …

Fully profiled chemical probes are essential to support the unbiased interpretation of
biological experiments necessary for rigorous preclinical target validation. We believe that …

The zebrafish has become a widely used model organism because of its fecundity, its
morphological and physiological similarity to mammals, the existence of many genomic tools …