To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …

Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …

Adapted plant pathogens from various microbial kingdoms produce hundreds of unrelated
small secreted proteins (SSPs) with elusive roles. Here, we used AlphaFold-Multimer (AFM) …

AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …

Protein–protein interactions (PPIs) regulate many cellular processes and engineered PPIs
have cell and gene therapy applications. Here, we introduce massively parallel PPI …

The revolution brought about by AlphaFold2 opens promising perspectives to unravel the
complexity of protein-protein interaction networks. The analysis of interaction networks …

PHT1 is a histidine/oligopeptide transporter with an essential role in Toll-like receptor innate
immune responses. It can act as a receptor by recruiting the adaptor protein TASL which …

AlphaFold2 (AF2) and RoseTTaFold (RF) have revolutionized structural biology, serving as
highly reliable and effective methods for predicting protein structures. This article explores …

Two years on from the initial release of AlphaFold, we have seen its widespread adoption as
a structure prediction tool. Here, we discuss some of the latest work based on AlphaFold …

Structural biology: A golden era | PLOS Biology Skip to main content Advertisement PLOS
Biology Browse Current Issue Journal Archive Collections Find and Read Articles Publish …