Biomedical data and computational models for drug repositioning: a comprehensive review

H Luo, M Li, M Yang, FX Wu, Y Li… - Briefings in …, 2021 - academic.oup.com
Drug repositioning can drastically decrease the cost and duration taken by traditional drug
research and development while avoiding the occurrence of unforeseen adverse events …

Recursive recurrent nets with attention modeling for ocr in the wild

CY Lee, S Osindero - … of the IEEE conference on computer …, 2016 - openaccess.thecvf.com
We present recursive recurrent neural networks with attention modeling (R2AM) for lexicon-
free optical character recognition in natural scene images. The primary advantages of the …

NCMCMDA: miRNA–disease association prediction through neighborhood constraint matrix completion

X Chen, LG Sun, Y Zhao - Briefings in bioinformatics, 2021 - academic.oup.com
Emerging evidence shows that microRNAs (miRNAs) play a critical role in diverse
fundamental and important biological processes associated with human diseases. Inferring …

[HTML][HTML] Machine learning for drug repositioning: Recent advances and challenges

L Cai, J Chu, J Xu, Y Meng, C Lu, X Tang… - Current Research in …, 2023 - Elsevier
Because translating the growing body of knowledge about human disease into treatments
has been slower than expected, the application of machine learning techniques to drug …

iDrug: Integration of drug repositioning and drug-target prediction via cross-network embedding

H Chen, F Cheng, J Li - PLoS computational biology, 2020 - journals.plos.org
Computational drug repositioning and drug-target prediction have become essential tasks in
the early stage of drug discovery. In previous studies, these two tasks have often been …

SNMFSMMA: using symmetric nonnegative matrix factorization and Kronecker regularized least squares to predict potential small molecule-microRNA association

Y Zhao, X Chen, J Yin, J Qu - RNA biology, 2020 - Taylor & Francis
Accumulating studies have shown that microRNAs (miRNAs) could be used as targets of
small-molecule (SM) drugs to treat diseases. In recent years, researchers have proposed …

A computational study of potential miRNA-disease association inference based on ensemble learning and kernel ridge regression

LH Peng, LQ Zhou, X Chen, X Piao - Frontiers in bioengineering and …, 2020 - frontiersin.org
As increasing experimental studies have shown that microRNAs (miRNAs) are closely
related to multiple biological processes and the prevention, diagnosis and treatment of …

Probabilistic and dynamic molecule-disease interaction modeling for drug discovery

T Fu, C Xiao, C Qian, LM Glass, J Sun - Proceedings of the 27th ACM …, 2021 - dl.acm.org
Drug discovery aims at finding promising drug molecules for treating target diseases.
Existing computational drug discovery methods mainly depend on molecule databases …

GK BertDTA: a graph representation learning and semantic embedding-based framework for drug-target affinity prediction

X Qiu, H Wang, X Tan, Z Fang - Computers in Biology and Medicine, 2024 - Elsevier
Developing new drugs is costly, time-consuming, and risky. Drug-target affinity (DTA),
indicating the binding capability between drugs and target proteins, is a crucial indicator for …

Modeling relational drug-target-disease interactions via tensor factorization with multiple web sources

H Chen, J Li - The World Wide Web Conference, 2019 - dl.acm.org
Modeling the behaviors of drug-target-disease interactions is crucial in the early stage of
drug discovery and holds great promise for precision medicine and personalized treatments …