Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Microglia and astrocytes in Alzheimer's disease: implications for therapy

M Fakhoury - Current neuropharmacology, 2018 - ingentaconnect.com
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's …

G Cui, H Guo, H Li, Y Zhai, Z Gong, J Wu, J Liu… - Immunity & …, 2019 - Springer
Background Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer
functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived …

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's …

M Losurdo, M Pedrazzoli, C D'Agostino… - Stem cells …, 2020 - academic.oup.com
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …

Alzheimer's disease, dementia, and stem cell therapy

T Duncan, M Valenzuela - Stem cell research & therapy, 2017 - Springer
Alzheimer's disease (AD) represents arguably the most significant social, economic, and
medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is …

[HTML][HTML] Stem cell therapy for Alzheimer's disease

XY Liu, LP Yang, L Zhao - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and cognitive impairment. It is caused by synaptic failure and excessive …

MSCs vs. iPSCs: Potential in therapeutic applications

K Thanaskody, AS Jusop, GJ Tye… - Frontiers in Cell and …, 2022 - frontiersin.org
Over the past 2 decades, mesenchymal stem cells (MSCs) have attracted a lot of interest as
a unique therapeutic approach for a variety of diseases. MSCs are capable of self-renewal …

Factors that influence adult neurogenesis as potential therapy

B Shohayeb, M Diab, M Ahmed, DCH Ng - Translational …, 2018 - Springer
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …

Innovative therapy for Alzheimer's disease-with focus on biodelivery of NGF

S Mitra, H Behbahani, M Eriksdotter - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …