In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease
characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby …

The present paradigms of selective autophagy in mammalian cells cannot fully explain the
specificity and selectivity of autophagic degradation. In this paper, we report that a subset of …

Tripartite motif (TRIM) proteins have been implicated in multiple cellular functions, including
antiviral activity. Research efforts so far indicate that the antiviral activity of TRIMs relies, for …

TRIM21 is a RING finger domain-containing ubiquitin E3 ligase whose expression is
elevated in autoimmune disease. While TRIM21 plays an important role in immune …

TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

Sjogren's syndrome is characterized by the presence of a plethora of autoantibodies (Table
1). We herein review major recent development in autoantibodies associated with Sjogren …