Metabolic reprogramming is a hallmark of cancer, which implements a profound metabolic
rewiring in order to support a high proliferation rate and to ensure cell survival in its complex …

Childhood adrenocortical tumors (ACTs) are rare, representing∼ 0.2% of all pediatric
malignancies and having an incidence of 0.2–0.3 new cases per million per year in the …

Introduction Surgery, followed or not by adjuvant mitotane, is the current mainstay of therapy
for patients with early-stage adrenocortical carcinoma (ACC). Mitotane, either alone or in …

Adrenocortical carcinoma (ACC) is a rare tumor with a poor prognosis. Most tumors are
either metastatic or locally invasive at the time of diagnosis. Differentiation between ACC …

Pharmacogenomics is based on the understanding of the individual differences in drug use,
the response to drug therapy (efficacy and toxicity), and the mechanisms underlying variable …

Background After radical resection, patients with adrenocortical carcinoma (ACC) frequently
experience recurrence and, therefore, effective adjuvant treatment is urgently needed. The …

Adrenocortical carcinoma (ACC) is a rare, highly aggressive cancer, often insensitive to
conventional chemotherapeutics agents. Early diagnosis, followed by radical surgical …

Simple Summary This is, to our knowledge, the first systematic review conducted on the
endocrine effects of mitotane, which aims to collect all available evidence in the literature …

AIM To determine the value of contrast-enhanced computed tomography (CT)-derived
radiomic features in the preoperative prediction of Ki-67 expression in adrenocortical …

Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation,
progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the …