The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

We sought to identify tumor-secreted factors that altered the frequency of MDSCs and
correlated with clinical outcomes in advanced melanoma patients. We focused our study on …

Members of the signal transducers and activators of transcription (STAT) pathway, which
were originally identified as key components linking cytokine signals to transcriptional …

Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …

Disruption of apoptosis may allow metastatic cell survival and confer resistance to
chemotherapeutic drugs. We have analysed the molecular pathways that activate these …

Inflammation is an important environmental factor that promotes tumourigenesis and the
progression of established cancerous lesions, and recent studies have started to dissect the …

STAT transcription factors are expressed in many cell types and bind to similar sequences.
However, different STAT gene knock-outs show very distinct phenotypes. To determine …

Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in
cell survival and proliferation. The aim of the present study was to clarify the role of STAT3 …