Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
A Sanchez, P Ortega, R Sakhtemani… - Nature …, 2024 - nature.com
Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of
mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially …
mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially …
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its
single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including …
single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including …
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism
The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the innate
antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and Kaposi's …
antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and Kaposi's …
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes
MK Wyllie, CK Morris, NH Moeller… - ACS Chemical …, 2024 - ACS Publications
The APOBEC3 family of polynucleotide cytidine deaminases has diverse roles as viral
restriction factors and oncogenic mutators. These enzymes convert cytidine to uridine in …
restriction factors and oncogenic mutators. These enzymes convert cytidine to uridine in …