Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality
of life and survival. Current treatment options are highly inadequate. As kidney function …

Abstract Fibroblast growth factor 23 (FGF23) is a hormone with a central role in the
regulation of phosphate homeostasis. This regulation is accomplished by the coordinated …

The term uraemic cardiomyopathy refers to the cardiac abnormalities that are seen in
patients with chronic kidney disease (CKD). Historically, this term was used to describe a …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Cardiovascular disease (CVD) is highly prevalent in the setting of chronic kidney disease
(CKD). Such coexistence of CVD and CKD—the so-called “cardiorenal or renocardiac …

The current focus on cardiovascular research reflects society's concerns regarding the
alarming incidence of cardiac-related diseases and mortality in the industrialized world and …

Abstract Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates
phosphate homeostasis in the kidney along with active vitamin D (1, 25 (OH) 2D3) and …