Ten principles of heterochromatin formation and function
RC Allshire, HD Madhani - Nature reviews Molecular cell biology, 2018 - nature.com
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …
particular genomic domains with specific functional properties. The capacity of …
[HTML][HTML] The sound of silence: Transgene silencing in mammalian cell engineering
A Cabrera, HI Edelstein, F Glykofrydis, KS Love… - Cell Systems, 2022 - cell.com
To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …
Role of mammalian DNA methyltransferases in development
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …
Mobile DNA in health and disease
HH Kazazian Jr, JV Moran - New England Journal of Medicine, 2017 - Mass Medical Soc
Mobile DNA in Health and Disease | New England Journal of Medicine Skip to main content
Access provided byMGH The New England Journal of Medicine homepage Advanced Search …
Access provided byMGH The New England Journal of Medicine homepage Advanced Search …
[HTML][HTML] Primate-specific transposable elements shape transcriptional networks during human development
The human genome contains more than 4.5 million inserts derived from transposable
elements (TEs), the result of recurrent waves of invasion and internal propagation …
elements (TEs), the result of recurrent waves of invasion and internal propagation …
Host–transposon interactions: conflict, cooperation, and cooption
RL Cosby, NC Chang, C Feschotte - Genes & development, 2019 - genesdev.cshlp.org
Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …
threaten genome integrity. As a result, several mechanisms appear to have emerged during …
[HTML][HTML] LTR-retrotransposon control by tRNA-derived small RNAs
Transposon reactivation is an inherent danger in cells that lose epigenetic silencing during
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons …
KRAB zinc finger proteins
G Ecco, M Imbeault, D Trono - Development, 2017 - journals.biologists.com
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …
transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB …
[HTML][HTML] Silencing and transcriptional regulation of endogenous retroviruses: an overview
FK Geis, SP Goff - Viruses, 2020 - mdpi.com
Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …
[HTML][HTML] Hominoid-specific transposable elements and KZFPs facilitate human embryonic genome activation and control transcription in naive human ESCs
Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene
expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling …
expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling …