A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites
reported in the scientific literature up through early 2013 is presented. This comprehensive …

We present here a broad overview of the field of metabolic engineering, describing in the
first section the key fundamental principles that define and distinguish it, as well as the …

Natural products continue to play a pivotal role in drug-discovery efforts and in the
understanding of human health. The ability to extend nature's chemistry through …

Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …

Covering: up to 2013The heterologous expression of microbial natural product biosynthetic
pathways coupled with advanced DNA engineering enables optimisation of product yields …

The need for new antimicrobials is indisputable. The flight from natural products in drug
discovery was unfortunate; however, the revolution that is genome mining, enabled by the …

Tetracyclines are a class of antibiotics that exhibited potent activity against a wide range of
Gram-positive and Gram-negative bacteria, yet only five members were isolated from …

Natural tetracycline (TC) antibiotics were the first major class of therapeutics to earn the
distinction of 'broad-spectrum antibiotics' and they have been used since the 1940s against …

Many bacteria and archaea produce the redox cofactor F420. F420 is structurally similar to
the cofactors FAD and FMN but is catalytically more similar to NAD and NADP. These …

Tetracyclines are a group of natural products sharing a linearly fused four-ring scaffold,
which is essential for their broad-spectrum antibiotic activities. Formation of the key …