High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein released by glia
and neurons upon inflammasome activation and activates receptor for advanced glycation …

Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …

Background Traumatic brain injury (TBI) causes 10–20% of acquired epilepsy, which
typically develops within 2 years post-injury with poorly understood mechanisms. We …

One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Hypometabolism, characterized by decreased brain glucose consumption, is a common
feature of many neurodegenerative diseases. Initial hypometabolic brain state, created by …

Epilepsy is a chronic disorder of the nervous system characterized by recurrent seizures.
Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of …

Traumatic brain injury (TBI) represents an important problem of global health. The damage
related to TBI is first due to the direct injury and then to a secondary phase in which …

Traumatic brain injury (TBI) is a leading cause of death and disability in young adults
worldwide. TBI survival is associated with persistent neuropsychiatric and neurological …