Apoptosis is an important biological process required for the removal of unwanted or
damaged cells. Mounting evidence implicates the actin cytoskeleton as both a sensor and …

Cytoskeletal abnormalities and synaptic loss, typical of both familial and sporadic Alzheimer
disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress …

Mitochondria perform diverse functions in the cell and their roles during processes such as
cell survival, differentiation, and migration are increasingly being appreciated. Mitochondrial …

Actin dynamics, the coordinated assembly and disassembly of actin filaments (F-actin), are
essential for fundamental cellular processes, including cell shaping and motility, cell division …

Cofilin is a member of the actin-depolymerizing factor (ADF) family protein, which plays an
essential role in regulation of the mitochondrial apoptosis. It remains unclear how cofilin …

DJ-1 is a redox sensitive protein with a wide range of functions related to oxidative stress
protection. Mutations in the park7 gene, which codes for DJ-1 are associated with early …

The dynamic nature of the actin cytoskeleton is required to coordinate many cellular
processes, and a loss of its plasticity has been linked to accelerated cell aging and …

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Despite the
availability of several treatment strategies, resistance to chemotherapeutic agents, which …

Abstract Cofilin-1 (CFL1) modulates dynamic actin networks by severing and enhancing
depolymerization. The upregulation of cofilin-1 expression in several cancer types is …

Cofilins are small protein of the actin depolymerizing family. Actin polymerization/
depolymerization is central to a number of critical cellular physiological tasks making cofilin …