The formation of C–aryl bonds has been the focus of intensive research over the last
decades for the construction of complex molecules from simple, readily available feedstocks …

Catalytic cross-coupling reactions of aromatic esters and amides have recently gained
considerable attention from synthetic chemists as de novo and efficient synthetic methods to …

Amides have been widely studied for decades, but their synthetic utility has remained limited
in reactions that proceed with rupture of the amide C–N bond. Using Ni catalysis, we have …

Metal-catalyzed cross-couplings represent one of the most important reaction platforms in
modern synthetic chemistry (Figure 1 A). 1 Although the field enjoys a rich history, there …

A direct enantioselective acylation of α-amino C (sp3)–H bonds with carboxylic acids has
been achieved via the merger of transition metal and photoredox catalysis. This …

A general aim of transition metal-catalysed organic synthesis is carbon–carbon (C–C) bond
formation. In this respect, the Pd-catalysed Suzuki–Miyaura (SM) coupling reaction 1 is one …

In organic molecules carboxylic acid groups are among the most common functionalities.
Activated derivatives of carboxylic acids have long served as versatile connection points in …

The Suzuki–Miyaura coupling is among the most important C–C bond-forming reactions
available due to its reliability, chemoselectivity, and diversity. Aryl halides and …

Highly chemoselective, palladium (0)-catalyzed, direct cross-coupling between boronic
acids and geometrically activated amides is reported. The reaction proceeds via selective …

This work highlights Ni-catalyzed reductive coupling of alkyl acids with alkyl halides,
particularly sterically hindered unactivated tertiary alkyl bromides for the production of all …