Recent advances on the mechanisms of kidney stone formation

Z Wang, Y Zhang, J Zhang… - … journal of molecular …, 2021 - spandidos-publications.com
Kidney stone disease is one of the oldest diseases known to medicine; however, the
mechanisms of stone formation and development remain largely unclear. Over the past …

Oxalate homeostasis

T Ermer, L Nazzal, MC Tio, S Waikar… - Nature Reviews …, 2023 - nature.com
Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

Lemon-derived extracellular vesicle-like nanoparticles block the progression of kidney stones by antagonizing endoplasmic reticulum stress in renal tubular cells

L Zhang, S Li, M Cong, Z Liu, Z Dong, M Zhao… - Nano Letters, 2023 - ACS Publications
Kidney stones, represented by the calcium oxalate (CaOx) type, are highly prevalent and
recrudescent. Cumulative evidence shows regular consumption of lemonade intervenes …

A non-classical view on calcium oxalate precipitation and the role of citrate

E Ruiz-Agudo, A Burgos-Cara, C Ruiz-Agudo… - Nature …, 2017 - nature.com
Although calcium oxalates are relevant biominerals, their formation mechanisms remain
largely unresolved. Here, we investigate the early stages of calcium oxalate formation in …

Role of additives in crystal nucleation from solutions: a review

S Xu, D Cao, Y Liu, Y Wang - Crystal Growth & Design, 2021 - ACS Publications
Nucleation is a key step in the crystallization of solution. For regulating and controlling this
process, it is thus critical to understand the nucleation mechanism under different …

Human kidney stones: a natural record of universal biomineralization

M Sivaguru, JJ Saw, EM Wilson, JC Lieske… - Nature Reviews …, 2021 - nature.com
GeoBioMed—a new transdisciplinary approach that integrates the fields of geology, biology
and medicine—reveals that kidney stones composed of calcium-rich minerals precipitate …

Multiple pathways for pathological calcification in the human body

N Vidavsky, JAMR Kunitake… - Advanced healthcare …, 2021 - Wiley Online Library
Biomineralization of skeletal components (eg, bone and teeth) is generally accepted to
occur under strict cellular regulation, leading to mineral–organic composites with …

Engineering crystal modifiers: bridging classical and nonclassical crystallization

KN Olafson, R Li, BG Alamani, JD Rimer - Chemistry of Materials, 2016 - ACS Publications
The use of growth modifiers in natural, biological, and synthetic crystallization is a ubiquitous
strategy for controlling growth and achieving desired physicochemical properties. For …

Molecular imposters functioning as versatile growth modifiers of urate crystallization

W Tang, C Smith, CB Parry, J Meegan… - Crystal Growth & …, 2023 - ACS Publications
Interactions between molecular modifiers and crystal surfaces govern numerous processes
and structural outcomes of natural, biological, and synthetic crystallization. An efficient …

Antimalarials inhibit hematin crystallization by unique drug–surface site interactions

KN Olafson, TQ Nguyen, JD Rimer… - Proceedings of the …, 2017 - National Acad Sciences
In malaria pathophysiology, divergent hypotheses on the inhibition of hematin crystallization
posit that drugs act either by the sequestration of soluble hematin or their interaction with …