The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …

Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …

Abstract See Hansson and Mormino (doi: 10.1093/brain/awy065) for a scientific commentary
on this article. Our objective was to compare different whole-brain and region-specific …

In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau
spreading pattern that does, however, not capture interindividual variability in tau deposition …

For many years Alzheimer's disease (AD) was associated with the dementia stage of the
disease, the tail end of a pathophysiological process that lasts approximately two decades …

The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …

Large phenotypically diverse research cohorts with both amyloid and tau PET have only
recently come into existence. Our objective was to determine relationships between the …

Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer's
disease. Understanding whether these features predict cognitive decline, alone or in …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Dementia, a chronic and progressive cognitive declination of brain function caused by
disease or impairment, is becoming more prevalent due to the aging population. A major …