Mechanistic and therapeutic relationships of traumatic brain injury and γ-amino-butyric acid (GABA)

JM Witkin, H Shafique, JL Smith, AM Marini… - Pharmacology & …, 2024 - Elsevier
Traumatic brain injury is a highly prevalent medical condition for which no medications
specific for the prophylaxis or treatment of the condition as a whole exist. The spectrum of …

[HTML][HTML] Metabolite changes and impact factors in mild traumatic brain injury patients: a review on magnetic resonance spectroscopy

S Huang, Y Lyu, T Liu, D Zhu - Meta-Radiology, 2024 - Elsevier
The high incidence of mild traumatic brain injury (mTBI) and the associated post-concussion
symptoms, such as headache and cognitive deficits, have captured the significant attention …

[HTML][HTML] Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect

ROG Tuura, A Buchmann, C Ritter, A Hase, M Haynes… - Brain Sciences, 2023 - mdpi.com
Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders,
with symptoms including persistent sadness and loss of interest. MDD is associated with …

[HTML][HTML] Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H] MRS and peripheral blood study

SE Watling, SG Rhind, J Warsh, D Green… - Frontiers in …, 2023 - frontiersin.org
Introduction Oxidative stress has been implicated in psychiatric disorders, including
posttraumatic stress disorder (PTSD). Currently, the status of glutathione (GSH), the brain's …

[HTML][HTML] Poor nutritional status is associated with incomplete functional recovery in elderly patients with mild traumatic brain injury

B Zhu, Y Ou, X Guo, W Liu, L Wu - Frontiers in Neurology, 2023 - frontiersin.org
Background The geriatric nutritional risk index (GNRI) is a simple index for evaluating the
nutrition status of elderly patients. Many investigations have demonstrated that this index is …

[HTML][HTML] Effects of isoflurane and urethane anesthetics on glutamate neurotransmission in rat brain using in vivo amperometry

JA Beitchman, G Krishna, CE Bromberg, TC Thomas - BMC neuroscience, 2023 - Springer
Background Aspects of glutamate neurotransmission implicated in normal and pathological
conditions are predominantly evaluated using in vivo recording paradigms in rats …

[HTML][HTML] Evaluating Back-to-Back and Day-to-Day Reproducibility of Cortical GABA+ Measurements Using Proton Magnetic Resonance Spectroscopy (1H MRS)

S Elsaid, P Truong, N Sailasuta, B Le Foll - International Journal of …, 2023 - mdpi.com
γ-aminobutyric acid (GABA) is a major inhibitory neurotransmitter implicated in
neuropsychiatric disorders. The best method for quantifying GABA is proton magnetic …

Visualizing Posttraumatic stress disorder with in vivo brain imaging: a multimodal approach

SE Watling - 2023 - search.proquest.com
Our limited understanding of biological mechanisms underpinning Posttraumatic Stress
Disorder (PTSD) is preventing effective drug development. Inflammation and oxidative stress …