Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its
association with an aggressive tumour phenotype and therapeutic resistance. Given its …

Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Purpose Hypoxia is a condition of insufficient oxygen to support metabolism which occurs
when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is …

Hypoxia is a hallmark of the tumor microenvironment and contributes to tumor malignant
phenotypes. Hypoxia-inducible factor (HIF) is a master regulator of intratumoral hypoxia and …

Purpose. To investigate the use of FDG-PET/CT before, during and after chemoradiotherapy
(CRT) and diffusion-weighted magnetic resonance imaging (DW-MRI) before CRT for the …

Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular
imaging allows to approach these variations, but the tracers used have their own limitations …

Hypoxia results from an imbalance between oxygen supply and consumption. It is a
common phenomenon in solid malignant tumors such as head and neck cancer. As hypoxic …

Purpose. The study presents the implementation of a novel method for incorporating hypoxia
information from PET-CT imaging into treatment planning and estimates the efficiency of …

Oxygen distribution is a major determinant of treatment success in radiotherapy, with well-
oxygenated tumour regions responding by up to a factor of three relative to anoxic volumes …

Purpose Delineation of tumour boundaries is important for quantification of [18 F] fluoro-2-
deoxy-D-glucose (FDG) positron emission tomography (PET) studies and for definition of …