The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection

R Mirzaei, F Mahdavi, F Badrzadeh… - International …, 2021 - Elsevier
The novel coronavirus disease 2019 (COVID-19) pandemic has imposed significant public
health problems for the human populations worldwide after the 1918 influenza A virus …

Danger‐associated molecular patterns (DAMPs) in acute lung injury

LB Tolle, TJ Standiford - The Journal of pathology, 2013 - Wiley Online Library
Danger‐associated molecular patterns (DAMPs) are host‐derived molecules that can
function to regulate the activation of pathogen recognition receptors (PRRs). These …

MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway

MJ Ju, BF Liu, HY He, ZY Gu, YM Liu, Y Su, DM Zhu… - Cell cycle, 2018 - Taylor & Francis
Acute lung injury (ALI) is a critical clinical condition with a high mortality rate, characterized
with excessive uncontrolled inflammation and apoptosis. Recently, microRNAs (miRNAs) …

Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3

X Yi, X Wei, H Lv, Y An, L Li, P Lu, Y Yang… - Experimental cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) have been widely documented for their potential role in the
treatment of various clinical disorders, including acute lung injury (ALI). ALI represents a …

Knockdown of LncRNA MALAT1 contributes to the suppression of inflammatory responses by up-regulating miR-146a in LPS-induced acute lung injury

L Dai, G Zhang, Z Cheng, X Wang, L Jia… - Connective Tissue …, 2018 - Taylor & Francis
Background: Acute lung injury (ALI) is a type of severe pulmonary inflammatory disease with
high rates of morbidity and mortality. Now, an increasing number of studies suggest that …

Role of microRNAs in lung development and pulmonary diseases

R Sessa, A Hata - Pulmonary circulation, 2013 - journals.sagepub.com
MicroRNAs (miRNAs) are a class of small noncoding RNA which exert post-transcriptional
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …

Microparticles and acute lung injury

M McVey, A Tabuchi… - American Journal of …, 2012 - journals.physiology.org
The pathophysiology of acute lung injury (ALI) and its most severe form, acute respiratory
distress syndrome (ARDS), is characterized by increased vascular and epithelial …

Cold exposure aggravates pulmonary arterial hypertension through increased miR-146a-5p, miR-155-5p and cytokines TNF-α, IL-1β, and IL-6

JL Sánchez-Gloria, R Carbó, M Buelna-Chontal… - Life Sciences, 2021 - Elsevier
Background Cold temperatures can aggravate pulmonary diseases and promote pulmonary
arterial hypertension (PAH); however, the underlying mechanism has not been fully …

PM2. 5 deregulated microRNA and inflammatory microenvironment in lung injury

G Liu, Y Li, J Zhou, J Xu, B Yang - Environmental Toxicology and …, 2022 - Elsevier
PM2. 5 negatively affects human health, particularly lung injury. However, the role of PM2. 5-
regulated miRNAs in lung injury remains unknown. MiRNA array results showed mmu-miR …

Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets

T Wang, C Gross, AA Desai… - … of Physiology-Lung …, 2017 - journals.physiology.org
Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory
failure due to acute respiratory distress syndrome (ARDS). Paradoxically, mechanical …