Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …

Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor

B Al-Fatly, S Ewert, D Kübler, D Kroneberg, A Horn… - Brain, 2019 - academic.oup.com
Essential tremor is the most prevalent movement disorder and is often refractory to medical
treatment. Deep brain stimulation offers a therapeutic approach that can efficiently control …

[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders

WJ Neumann, RS Turner, B Blankertz, T Mitchell… - …, 2019 - Elsevier
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …

Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor

M Scherer, LA Steiner, SK Kalia… - Proceedings of the …, 2022 - National Acad Sciences
Deep brain stimulation procedures offer an invaluable opportunity to study disease through
intracranial recordings from awake patients. Here, we address the relationship between …

[HTML][HTML] Clinical neurophysiology of Parkinson's disease and parkinsonism

R Chen, A Berardelli, A Bhattacharya… - Clinical neurophysiology …, 2022 - Elsevier
This review is part of the series on the clinical neurophysiology of movement disorders. It
focuses on Parkinson's disease and parkinsonism. The topics covered include the …

[HTML][HTML] Deep brain stimulation: Imaging on a group level

S Treu, B Strange, S Oxenford, WJ Neumann, A Kühn… - Neuroimage, 2020 - Elsevier
Abstract Deep Brain Stimulation (DBS) is an established treatment option for movement
disorders and is under investigation for treatment in a growing number of other brain …

The dentato-rubro-thalamic tract as the potential common deep brain stimulation target for tremor of various origin: an observational case series

VA Coenen, B Sajonz, T Prokop, M Reisert, T Piroth… - Acta …, 2020 - Springer
Introduction Deep brain stimulation alleviates tremor of various origins. The dentato-rubro-
thalamic tract (DRT) has been suspected as a common tremor-reducing structure. Statistical …

Deep brain stimulation: a review of the open neural engineering challenges

M Vissani, IU Isaias, A Mazzoni - Journal of neural engineering, 2020 - iopscience.iop.org
Objective. Deep brain stimulation (DBS) is an established and valid therapy for a variety of
pathological conditions ranging from motor to cognitive disorders. Still, much of the DBS …

A review on pathology, mechanism, and therapy for cerebellum and tremor in Parkinson's disease

Y Zhong, H Liu, G Liu, L Zhao, C Dai, Y Liang… - npj Parkinson's …, 2022 - nature.com
Tremor is one of the core symptoms of Parkinson's disease (PD), but its mechanism is poorly
understood. The cerebellum is a growing focus in PD-related researches and is reported to …