Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

The underlying neurobiological basis of major depressive disorder remains elusive due to
the severity, complexity, and heterogeneity of the disorder. While the traditional …

Stress is a major risk factor in the onset of several neuropsychiatric disorders including
anxiety and depression. Although several studies have shown that social isolation stress …

Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Aerobic exercise (AE) has been widely praised for its potential benefits to cognition and
overall brain and mental health. In particular, AE has a potent impact on promoting the …

Glucocorticoids serve as key stress response hormones that facilitate stress coping.
However, sustained glucocorticoid exposure is associated with adverse consequences on …

Recent compelling evidence has suggested that the glutamate system is a primary mediator
of psychiatric pathology and also a target for rapid-acting antidepressants. Clinical research …

Essentially all cells contain a variety of spatially restricted regions that are important for
carrying out specialized functions. Often, these regions contain specialized transcriptomes …

Depression is a debilitating mental disease, characterized by persistent low mood and
anhedonia. Stress represents a major environmental risk factor for depression; the complex …

Aerobic exercise (AE) benefits brain health and behavior. Serotonin (5-HT) and brain-
derived neurotrophic factor (BDNF) are known to mediate and shape cognitive processes …