Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify
their risk factors and causative mechanisms due to their multifactorial nature, the limited …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Telomere length is a promising biomarker for age-related disease and a potential anti-
ageing drug target. Here, we study the genetic architecture of telomere length and the …

Mood disorders are associated with an increased risk of aging-related diseases, which
greatly contribute to the excess morbidity and mortality observed in affected individuals …

With an ever-ageing population in developed countries, healthy ageing is an emerging
public health priority for securing citizens' quality of life and minimizing healthcare …

Background Major depressive disorder (MDD) poses a significant social and economic
burden worldwide. Identifying exposures, risk factors, and biological mechanisms that are …

The risk of depression could be evaluated through its multifactorial nature using the
polygenic score (PGS) approach. Assuming a “clinical continuum” hypothesis of mental …

Telomere length has been subject of studies for many decades, aiming to elucidate its role
in physiological processes, in process of aging and in diverse pathologies. Yet today, there …

We define and discuss several proposed biological aging markers that have been examined
in SMDs, we review the most recent findings, and we conclude with opinions regarding the …