Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …

Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

Cardiometabolic disease (CMD), characterized with metabolic disorder triggered
cardiovascular events, is a leading cause of death and disability. Metabolic disorders trigger …

Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …

Transcription factor EB (TFEB) is considered the master transcriptional regulator of
autophagy and lysosomal biogenesis, which regulates target gene expression through …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling system
regulates a variety of biological processes, including embryogenesis, angiogenesis, wound …

Bile acids (BAs) are produced from cholesterol in the liver and are termed primary BAs.
Primary BAs are conjugated with glycine and taurine in the liver and then released into the …

Old age is associated with a greater burden of disease, including neurodegenerative
disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic …

Bacterial infections are among the major factors that cause stress and intestinal diseases in
piglets. Lipopolysaccharide (LPS), a major component of the Gram‐negative bacteria outer …