Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics

C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …

Paracrine mechanisms of mesenchymal stromal cells in angiogenesis

S Maacha, H Sidahmed, S Jacob… - Stem cells …, 2020 - Wiley Online Library
The role of the mesenchymal stromal cell‐(MSC‐) derived secretome is becoming
increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous …

[HTML][HTML] Cryopreservation and its clinical applications

TH Jang, SC Park, JH Yang, JY Kim, JH Seok… - Integrative medicine …, 2017 - Elsevier
Cryopreservation is a process that preserves organelles, cells, tissues, or any other
biological constructs by cooling the samples to very low temperatures. The responses of …

To protect and to preserve: novel preservation strategies for extracellular vesicles

GD Kusuma, M Barabadi, JL Tan… - Frontiers in …, 2018 - frontiersin.org
Extracellular vesicles (EVs)-based therapeutics are based on the premise that EVs shed by
stem cells exert similar therapeutic effects and these have been proposed as an alternative …

The therapeutic potential of three-dimensional multipotent mesenchymal stromal cell spheroids

Y Petrenko, E Syková, Š Kubinová - Stem cell research & therapy, 2017 - Springer
The efficiency of clinical trials involving transplantation of multipotent mesenchymal stromal
cells (MSCs) is often insufficient due to harsh conditions present within the target tissue …

Cryopreservation as a key element in the successful delivery of cell-based therapies—a review

J Meneghel, P Kilbride, GJ Morris - Frontiers in medicine, 2020 - frontiersin.org
Cryopreservation is a key enabling technology in regenerative medicine that provides stable
and secure extended cell storage for primary tissue isolates and constructs and prepared …

Synergistic interplay between human MSCs and HUVECs in 3D spheroids laden in collagen/fibrin hydrogels for bone tissue engineering

DN Heo, M Hospodiuk, IT Ozbolat - Acta biomaterialia, 2019 - Elsevier
Stem cell encapsulation in hydrogels has been widely employed in tissue engineering,
regenerative medicine, organ-on-a-chip devices and gene delivery; however, fabrication of …

Concise review: bioprinting of stem cells for transplantable tissue fabrication

AN Leberfinger, DJ Ravnic, A Dhawan… - Stem cells …, 2017 - academic.oup.com
Bioprinting is a quickly progressing technology, which holds the potential to generate
replacement tissues and organs. Stem cells offer several advantages over differentiated …

Explant culture: An advantageous method for isolation of mesenchymal stem cells from human tissues

F Hendijani - Cell proliferation, 2017 - Wiley Online Library
Mesenchymal stem cell (MSC) research progressively moves towards clinical phases.
Accordingly, a wide range of different procedures were presented in the literature for MSC …