Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic
liver disease worldwide and closely interconnected to the metabolic syndrome. Liver …

Background: Studies characterizing associations between phenols, phthalates and thyroid
hormones during pregnancy produce inconsistent results. This divergence may be partly …

Background: Thyroid hormone receptors (TRs) are critical endocrine receptors that regulate
a multitude of processes in adult and developing organisms, and thyroid hormone disruption …

This review summarises the current state of knowledge regarding the physiology and control
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …

High-throughput screening (HTS) and computational technologies have emerged as
important tools for chemical hazard identification. The US Environmental Protection Agency …

Abstract The US Environmental Protection Agency is evaluating the ecological and
toxicological effects of per-and polyfluorinated chemicals. A number of perfluorinated …

Deiodinase enzymes play an essential role in converting thyroid hormones between active
and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone …

Developmentally neurotoxic chemicals are a diverse set of substances that have the
potential to interfere with the normal development of the nervous system, which, if perturbed …