Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …
and execution of flexible behavior. Models of how the basal ganglia subserve these …
Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation
Symptoms of neurological diseases emerge through the dysfunction of neural circuits whose
diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep …
diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep …
The indirect pathway of the basal ganglia promotes transient punishment but not motor suppression
Optogenetic stimulation of Adora2a receptor-expressing spiny projection neurons (A2A-
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
SPNs) in the striatum drives locomotor suppression and transient punishment, results …
Ventral pallidal regulation of motivated behaviors and reinforcement
C Soares-Cunha, JA Heinsbroek - Frontiers in Neural Circuits, 2023 - frontiersin.org
The interconnected nuclei of the ventral basal ganglia have long been identified as key
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …
Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment
THC Cheung, Y Ding, X Zhuang… - Proceedings of the …, 2023 - National Acad Sciences
Dopamine (DA) loss in Parkinson's disease (PD) causes debilitating motor deficits.
However, dopamine is also widely linked to reward prediction and learning, and the …
However, dopamine is also widely linked to reward prediction and learning, and the …
External segment of the globus pallidus in health and disease: Its interactions with the striatum and subthalamic nucleus
A Nambu, S Chiken - Neurobiology of Disease, 2024 - Elsevier
The external segment of the globus pallidus (GPe) has long been considered a
homogeneous structure that receives inputs from the striatum and sends processed …
homogeneous structure that receives inputs from the striatum and sends processed …
Dissociable roles of pallidal neuron subtypes in regulating motor patterns
We have previously established that PV+ neurons and Npas1+ neurons are distinct neuron
classes in the external globus pallidus (GPe): they have different topographical …
classes in the external globus pallidus (GPe): they have different topographical …
Molecular, circuit, and stress response characterization of ventral pallidum Npas1-neurons
G Morais-Silva, RR Campbell, H Nam… - Journal of …, 2023 - Soc Neuroscience
Altered activity of the ventral pallidum (VP) underlies disrupted motivation in stress and drug
exposure. The VP is a very heterogeneous structure composed of many neuron types with …
exposure. The VP is a very heterogeneous structure composed of many neuron types with …
A non-canonical striatopallidal Go pathway that supports motor control
In the classical model of the basal ganglia, direct pathway striatal projection neurons
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …
(dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to …