Plant breeding has a long history of developing new varieties that have ensured the food
security of the human population. During this long journey together with humanity, plant …

As boreal forests face significant threats from climate change, understanding evolutionary
trajectories of coniferous species has become fundamental to adapting management and …

A bstract Background Differentiating between cancer patients who will experience
metastasis within a short time and who will be long-term survivors without metastasis is a …

Introduction: Pseudoxanthoma elasticum (PXE), an ectopic mineralization disorder caused
by pathogenic ABCC6 variants, is characterized by skin, ocular and cardiovascular (CV) …

In genetic association studies of rare variants, the low power of association tests is one of
the main challenges. In this study, we propose a new single‐marker association test called …

Introduction Polymorphism of the glucocorticoid receptor gene (NR3C1) may modify protein
abundance or function and therefore disturb human homeostasis. Methods Variant …

Various statistical methods can be applied when undertaking analyses of association of
human disease and traits with rare genetic variants in next generation sequence (NGS) …

For precision medicine and personalized treatment, we need to identify predictive markers of
disease. We focus on Alzheimer's disease (AD), where magnetic resonance imaging scans …

Materials and Methods: Mixed effects of rare variants were assessed by Whole Exome
Sequencing in 11 PXE patients with an extreme CV phenotype (mild/severe). Statistical …

Several haplotype-based methods have been developed to identify loci where multiple
mutations of low to moderate frequency and effect size modulate disease susceptibility. Most …