Tau and neurodegenerative disease: the story so far
In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain.
In the previous year, a paired helical filament (PHF) protein had been identified in …
In the previous year, a paired helical filament (PHF) protein had been identified in …
The rise of harmful cyanobacteria blooms: the potential roles of eutrophication and climate change
Cyanobacteria are the most ancient phytoplankton on the planet and form harmful algal
blooms in freshwater, estuarine, and marine ecosystems. Recent research suggests that …
blooms in freshwater, estuarine, and marine ecosystems. Recent research suggests that …
Parkinson's disease: a multisystem disorder
HN Costa, AR Esteves, N Empadinhas… - Neuroscience Bulletin, 2023 - Springer
The way sporadic Parkinson's disease (PD) is perceived has undergone drastic changes in
recent decades. For a long time, PD was considered a brain disease characterized by motor …
recent decades. For a long time, PD was considered a brain disease characterized by motor …
Cyanobacterial toxins: Modes of actions, fate in aquatic and soil ecosystems, phytotoxicity and bioaccumulation in agricultural crops
S Corbel, C Mougin, N Bouaïcha - Chemosphere, 2014 - Elsevier
The occurrence of harmful cyanobacterial blooms in surface waters is often accompanied by
the production of a variety of cyanotoxins. These toxins are designed to target in humans …
the production of a variety of cyanotoxins. These toxins are designed to target in humans …
Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
Neurofibrillary tangles (NFT) and β-amyloid plaques are the neurological hallmarks of both
Alzheimer's disease and an unusual paralytic illness suffered by Chamorro villagers on the …
Alzheimer's disease and an unusual paralytic illness suffered by Chamorro villagers on the …
The non-protein amino acid BMAA is misincorporated into human proteins in place of L-serine causing protein misfolding and aggregation
Mechanisms of protein misfolding are of increasing interest in the aetiology of
neurodegenerative diseases characterized by protein aggregation and tangles including …
neurodegenerative diseases characterized by protein aggregation and tangles including …
Diverse taxa of cyanobacteria produce β-N-methylamino-l-alanine, a neurotoxic amino acid
Cyanobacteria can generate molecules hazardous to human health, but production of the
known cyanotoxins is taxonomically sporadic. For example, members of a few genera …
known cyanotoxins is taxonomically sporadic. For example, members of a few genera …
Human health risk assessment related to cyanotoxins exposure
E Funari, E Testai - Critical reviews in toxicology, 2008 - Taylor & Francis
This review focuses on the risk assessment associated with human exposure to cyanotoxins,
secondary metabolites of an ubiquitous group of photosynthetic procariota. Cyanobacteria …
secondary metabolites of an ubiquitous group of photosynthetic procariota. Cyanobacteria …
ALS: A bucket of genes, environment, metabolism and unknown ingredients
M Zufiria, FJ Gil-Bea, R Fernandez-Torron… - Progress in …, 2016 - Elsevier
The scientific scenario of amyotrophic lateral sclerosis (ALS) has dramatically changed
since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal …
since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal …
A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis
D Di Gioia, N Bozzi Cionci, L Baffoni, A Amoruso… - BMC medicine, 2020 - Springer
Background A connection between amyotrophic lateral sclerosis (ALS) and altered gut
microbiota composition has previously been reported in animal models. This work is the first …
microbiota composition has previously been reported in animal models. This work is the first …