Nanoparticle contrast agents for X‐ray imaging applications

JC Hsu, LM Nieves, O Betzer, T Sadan… - Wiley …, 2020 - Wiley Online Library
X‐ray imaging is the most widely used diagnostic imaging method in modern medicine and
several advanced forms of this technology have recently emerged. Iodinated molecules and …

Advances in imaging strategies for in vivo tracking of exosomes

O Betzer, E Barnoy, T Sadan, I Elbaz… - Wiley …, 2020 - Wiley Online Library
Exosomes have many biological functions as short‐and long distance nanocarriers for cell‐
to‐cell communication. They allow the exchange of complex information between cells, and …

Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury

S Guo, N Perets, O Betzer, S Ben-Shaul, A Sheinin… - ACS …, 2019 - ACS Publications
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits,
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …

Golden exosomes selectively target brain pathologies in neurodegenerative and neurodevelopmental disorders

N Perets, O Betzer, R Shapira, S Brenstein, A Angel… - Nano …, 2019 - ACS Publications
Exosomes, nanovesicles that are secreted by different cell types, enable intercellular
communication at local or distant sites. Alhough they have been found to cross the blood …

In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles

O Betzer, N Perets, A Angel, M Motiei, T Sadan… - ACS …, 2017 - ACS Publications
Exosomes are emerging as effective therapeutic tools for various pathologies. These
extracellular vesicles can bypass biological barriers, including the blood-brain barrier, and …

Fast image-guided stratification using anti-programmed death ligand 1 gold nanoparticles for cancer immunotherapy

R Meir, K Shamalov, T Sadan, M Motiei, G Yaari… - ACS …, 2017 - ACS Publications
Cancer immunotherapy has made enormous progress in offering safer and more effective
treatments for the disease. Specifically, programmed death ligand 1 antibody (αPDL1) …

Bismuth nanomaterials as contrast agents for radiography and computed tomography imaging and their quality/safety considerations

H Yu, H Guo, Y Wang, Y Wang… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Contrast agents for radiography and computed tomography (CT) scans are substances that
can enhance the contrast of blood vessels and soft tissue with detailed imaging information …

Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy

Y Chemla, O Betzer, A Markus, N Farah, M Motiei… - …, 2019 - Taylor & Francis
Aim: Longitudinal tracking of transplanted cells in clinical and experimental setups is crucial
for evaluating the efficiency of retinal cell replacement therapies. Materials & methods: Gold …

Nanoparticles for stem cell tracking and the potential treatment of cardiovascular diseases

H Huang, X Du, Z He, Z Yan, W Han - Frontiers in Cell and …, 2021 - frontiersin.org
Stem cell-based therapies have been shown potential in regenerative medicine. In these
cells, mesenchymal stem cells (MSCs) have the ability of self-renewal and being …

Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier

O Betzer, M Shilo, M Motiei… - … Imaging, Sensing, and …, 2019 - spiedigitallibrary.org
A major challenge for treatment of neurodegenerative disorders is the need to overcome the
restrictive mechanism of the blood-brain-barrier (BBB) for delivery of therapeutic agents into …