Sex steroid receptors are ligand-triggered transcription factors. Oestrogen, progesterone
and androgen receptors form, together with the glucocorticoid and mineralocorticoid …

The progesterone receptor is able to bind to a large number and variety of ligands that elicit
a broad range of transcriptional responses ranging from full agonism to full antagonism and …

The direct enantioselective chiral calcium (II)· phosphate complex (Ca [CPA] 2)-catalyzed
conjugate addition of unprotected alkyl amines to maleimides was developed. This mild …

The existence of preferred molecular scaffolds that possess inherent biological activity,
called privileged structures, is now well recognized. Such privileged structures not only …

Solid-Phase Synthesis of N-Substituted Pyrrolidinone-Tethered N-Substituted Piperidines via
Ugi Reaction | ACS Combinatorial Science ACS ACS Publications C&EN CAS Find my …

The previously reported pyrrolidine class of progesterone receptor partial agonists
demonstrated excellent potency but suffered from serious liabilities including hERG …

Herein, the synthesis of 4-methyldecarboxyhaumanamide (9) and 4-
methyldecarboxyspongolactams A (11) and C (13) is presented.(−)-Sclareol is the starting …

Chiral amines are a ubiquitous motif in pharmaceuticals and natural products (FIG. 1). The
conjugate addition of 50 amine nucleophiles to various a, ß-unsaturated systems is a well …

Synthesis of novel hybrid derivatives of two known scaffolds, pyrrolidine-2-one and
piperazine, is described. Initially, the Ugi reaction of phenylglyoxal, aromatic amines …

The steroid hormone receptors, the Androgen Receptor (AR), Estrogen Receptors (ERα and
ERβ), Glucocorticoid Receptor (GR), Mineralocorticoid Receptor and Progesterone …