Evolving therapeutic landscape of advanced hepatocellular carcinoma
C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
Rational combinations of targeted cancer therapies: background, advances and challenges
H Jin, L Wang, R Bernards - Nature Reviews Drug Discovery, 2023 - nature.com
Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …
SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …
Engineered exosomes from different sources for cancer-targeted therapy
M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …
Precision oncology in metastatic colorectal cancer—from biology to medicine
Remarkable progress has been made in the development of biomarker-driven targeted
therapies for patients with multiple cancer types, including melanoma, breast and lung …
therapies for patients with multiple cancer types, including melanoma, breast and lung …
Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy
Arsenical drugs have achieved hallmark success in treating patients with acute
promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult …
promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult …
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health
Traditional herbal medicine (THM), an ancient science, is a gift from nature. For thousands of
years, it has helped humans fight diseases and protect life, health, and reproduction …
years, it has helped humans fight diseases and protect life, health, and reproduction …
Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety …
L Zhang, F He, L Gao, M Cong, J Sun, J Xu… - International Journal …, 2021 - Taylor & Francis
Background Exosomes are a type of membrane vesicles secreted by living cells. Recent
studies suggest exosome-like nanovesicles (ELNVs) from fruits and vegetables are involved …
studies suggest exosome-like nanovesicles (ELNVs) from fruits and vegetables are involved …
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer
UN Wasko, J Jiang, TC Dalton, A Curiel-Garcia… - Nature, 2024 - nature.com
Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human
cancer patients whose tumors are driven by RAS mutations1, 2. RMC-7977 is a highly …
cancer patients whose tumors are driven by RAS mutations1, 2. RMC-7977 is a highly …
Rational cancer treatment combinations: an urgent clinical need
J Boshuizen, DS Peeper - Molecular cell, 2020 - cell.com
We are witnessing several revolutionary technological advances in cancer. These
innovations have not only contributed to a growing understanding of the tumor and its …
innovations have not only contributed to a growing understanding of the tumor and its …