Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Rational combinations of targeted cancer therapies: background, advances and challenges

H Jin, L Wang, R Bernards - Nature Reviews Drug Discovery, 2023 - nature.com
Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …

SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets

S Zheng, W Wang, J Aldahdooh… - Genomics …, 2022 - academic.oup.com
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …

Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

Precision oncology in metastatic colorectal cancer—from biology to medicine

F Di Nicolantonio, PP Vitiello, S Marsoni… - Nature reviews Clinical …, 2021 - nature.com
Remarkable progress has been made in the development of biomarker-driven targeted
therapies for patients with multiple cancer types, including melanoma, breast and lung …

Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy

C Liu, S Sun, Q Feng, G Wu, Y Wu, N Kong… - Advanced …, 2021 - Wiley Online Library
Arsenical drugs have achieved hallmark success in treating patients with acute
promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult …

Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health

J Zhang, K Hu, L Di, P Wang, Z Liu, J Zhang… - Advanced drug delivery …, 2021 - Elsevier
Traditional herbal medicine (THM), an ancient science, is a gift from nature. For thousands of
years, it has helped humans fight diseases and protect life, health, and reproduction …

Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety …

L Zhang, F He, L Gao, M Cong, J Sun, J Xu… - International Journal …, 2021 - Taylor & Francis
Background Exosomes are a type of membrane vesicles secreted by living cells. Recent
studies suggest exosome-like nanovesicles (ELNVs) from fruits and vegetables are involved …

Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer

UN Wasko, J Jiang, TC Dalton, A Curiel-Garcia… - Nature, 2024 - nature.com
Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human
cancer patients whose tumors are driven by RAS mutations1, 2. RMC-7977 is a highly …

Rational cancer treatment combinations: an urgent clinical need

J Boshuizen, DS Peeper - Molecular cell, 2020 - cell.com
We are witnessing several revolutionary technological advances in cancer. These
innovations have not only contributed to a growing understanding of the tumor and its …