Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: a Mendelian randomization analysis …

S Rao, A Lau, HC So - Diabetes care, 2020 - Am Diabetes Assoc
OBJECTIVE COVID-19 has become a major public health problem. There is good evidence
that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase …

Data-driven hypothesis weighting increases detection power in genome-scale multiple testing

N Ignatiadis, B Klaus, JB Zaugg, W Huber - Nature methods, 2016 - nature.com
Hypothesis weighting improves the power of large-scale multiple testing. We describe
independent hypothesis weighting (IHW), a method that assigns weights using covariates …

A practical guide to methods controlling false discoveries in computational biology

K Korthauer, PK Kimes, C Duvallet, A Reyes… - Genome biology, 2019 - Springer
Background In high-throughput studies, hundreds to millions of hypotheses are typically
tested. Statistical methods that control the false discovery rate (FDR) have emerged as …

MultipleTesting. com: A tool for life science researchers for multiple hypothesis testing correction

O Menyhart, B Weltz, B Győrffy - PloS one, 2021 - journals.plos.org
Scientists from nearly all disciplines face the problem of simultaneously evaluating many
hypotheses. Conducting multiple comparisons increases the likelihood that a non-negligible …

Bayesian inference and testing of group differences in brain networks

D Durante, DB Dunson - 2018 - projecteuclid.org
Bayesian Inference and Testing of Group Differences in Brain Networks Page 1 Bayesian Analysis
(2018) 13, Number 1, pp. 29–58 Bayesian Inference and Testing of Group Differences in Brain …

Slotting metabolomics into routine precision medicine

M Mussap, A Noto, C Piras, L Atzori… - Expert Review of …, 2021 - Taylor & Francis
Introduction Despite an impressive amount of metabolomics studies in animal models and
humans, most findings have not yet translated into the clinical setting, and the road ahead …

[HTML][HTML] Network classification with applications to brain connectomics

JDA Relión, D Kessler, E Levina… - The annals of applied …, 2019 - ncbi.nlm.nih.gov
While statistical analysis of a single network has received a lot of attention in recent years,
with a focus on social networks, analysis of a sample of networks presents its own …

DeepLINK: Deep learning inference using knockoffs with applications to genomics

Z Zhu, Y Fan, Y Kong, J Lv… - Proceedings of the …, 2021 - National Acad Sciences
We propose a deep learning–based knockoffs inference framework, DeepLINK, that
guarantees the false discovery rate (FDR) control in high-dimensional settings. DeepLINK is …

Covariate-assisted ranking and screening for large-scale two-sample inference

T Tony Cai, W Sun, W Wang - Journal of the Royal Statistical …, 2019 - academic.oup.com
Two-sample multiple testing has a wide range of applications. The conventional practice first
reduces the original observations to a vector of p-values and then chooses a cut-off to adjust …

A direct approach to estimating false discovery rates conditional on covariates

SM Boca, JT Leek - PeerJ, 2018 - peerj.com
Modern scientific studies from many diverse areas of research abound with multiple
hypothesis testing concerns. The false discovery rate (FDR) is one of the most commonly …