Aromatic oligoamide foldamers possess a high potential for mimicking the secondary
structures of biopolymers. These oligomers are efficiently designed, easy to synthesize, and …

This review discusses chiral self-sorting the process of choosing an interaction partner with
a given chirality from a complex mixture of many possible racemic partners. Chiral self …

Interactions among β-sheets occur widely in protein quaternary structure, protein–protein
interaction, and protein aggregation and are central in Alzheimer's and other amyloid …

What I cannot create, I do not understand. Richard P. Feynman β-Sheets consist of
extended polypeptide strands (β-strands) connected by a network of hydrogen bonds and …

The simplest peptide structural element is the peptide β-strand. The β-strand is a linear or
sawtoothed arrangement of amino acids with amide bonds being almost coplanar, side …

This paper describes the synthesis and characterization of the first series of hydrogen
bonding-driven hydrazide foldamers and their recognition for alkyl saccharides in …

Most peptide drugs contain non-proteinogenic amino acids (NPAAs), born out through
extensive structure–activity relationship (SAR) studies using solid-phase peptide synthesis …

Different classes of foldamers, which are synthetic oligomers that adopt well-defined
conformations in solution, have been the subject of extensive studies devoted to the …

This paper describes studies of a series of macrocyclic β-sheet peptides 1 that inhibit the
aggregation of a tau-protein-derived peptide. The macrocyclic β-sheet peptides comprise a …

High-resolution structures of oligomers formed by the β-amyloid peptide Aβ are needed to
understand the molecular basis of Alzheimer's disease and develop therapies. This paper …