[HTML][HTML] Combination therapy in combating cancer
RB Mokhtari, TS Homayouni, N Baluch… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …
p27Kip1 and human cancers: A reappraisal of a still enigmatic protein
D Bencivenga, I Caldarelli, E Stampone, FP Mancini… - Cancer letters, 2017 - Elsevier
Abstract p27 Kip1 is a cell cycle regulator firstly identified as a cyclin-dependent kinase
inhibitor. For a long time, its function has been associated to cell cycle progression inhibition …
inhibitor. For a long time, its function has been associated to cell cycle progression inhibition …
[HTML][HTML] SKping cell cycle regulation: role of ubiquitin ligase SKP2 in hematological malignancies
JNG William, R Dhar, R Gundamaraju… - Frontiers in …, 2024 - frontiersin.org
SKP2 (S-phase kinase-associated protein 2) is a member of the F-box family of substrate-
recognition subunits in the SCF ubiquitin-protein ligase complexes. It is associated with …
recognition subunits in the SCF ubiquitin-protein ligase complexes. It is associated with …
Targeting histone deacetylases in malignant melanoma: a future therapeutic agent or just great expectations?
N Garmpis, C Damaskos, A Garmpi… - Anticancer …, 2017 - ar.iiarjournals.org
Background/Aim: Malignant melanoma is the most aggressive type of skin cancer, with
increasing frequency and mortality. Melanoma is characterized by rapid proliferation and …
increasing frequency and mortality. Melanoma is characterized by rapid proliferation and …
N-Myc transcriptionally activates Skp2 to suppress p27 expression in small cell lung cancer
J Zou, Y Lin, M Hu, M Wan, X Tan, X Xu, F Xu - Pathology-Research and …, 2022 - Elsevier
Background Small cell lung cancer (SCLC) is characterized by a high proliferative rate, a
strong predilection for early metastasis and poor prognosis. Novel SCLC biomarkers are …
strong predilection for early metastasis and poor prognosis. Novel SCLC biomarkers are …
[HTML][HTML] p57Kip2 Phosphorylation Modulates Its Localization, Stability, and Interactions
E Stampone, D Bencivenga, L Dassi, S Sarnelli… - International Journal of …, 2024 - mdpi.com
p57Kip2 is a member of the cyclin-dependent kinase (CDK) Interacting Protein/Kinase
Inhibitory Protein (CIP/Kip) family that also includes p21Cip1/WAF1 and p27Kip1. Different …
Inhibitory Protein (CIP/Kip) family that also includes p21Cip1/WAF1 and p27Kip1. Different …
Histone Deacetylases in Retinoblastoma
M Lisek, J Tomczak, J Swiatek, A Kaluza… - International Journal of …, 2024 - mdpi.com
Retinoblastoma, a pediatric ocular malignancy, presents significant challenges in
comprehending its molecular underpinnings and targeted therapeutic approaches. The …
comprehending its molecular underpinnings and targeted therapeutic approaches. The …
A Beckwith–Wiedemann-Associated CDKN1C Mutation Allows the Identification of a Novel Nuclear Localization Signal in Human p57Kip2
E Stampone, D Bencivenga, C Barone… - International Journal of …, 2021 - mdpi.com
p57Kip2 protein is a member of the CIP/Kip family, mainly localized in the nucleus where it
exerts its Cyclin/CDKs inhibitory function. In addition, the protein plays key roles in …
exerts its Cyclin/CDKs inhibitory function. In addition, the protein plays key roles in …
MicroRNA-186 targets SKP2 to induce p27Kip1-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation
Z He, L Chen, Q Wang, C Yin, J Hu… - The Korean Journal …, 2019 - synapse.koreamed.org
Pituitary tumors are usually benign but can occasionally exhibit hormonal and proliferative
behaviors. Dysregulation of the G1/S restriction point largely contributes to the over …
behaviors. Dysregulation of the G1/S restriction point largely contributes to the over …
[HTML][HTML] Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity
M Ogawa, T Yaginuma, C Nakatomi, T Nakajima… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Melanoma, one of the most aggressive neoplasms, is characterized by rapid cell
proliferation. Transducin-like Enhancer of Split (TLE) is an important regulator of cell …
proliferation. Transducin-like Enhancer of Split (TLE) is an important regulator of cell …