[HTML][HTML] Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Engineering multi‐cellular spheroids for tissue engineering and regenerative medicine

S Kim, EM Kim, M Yamamoto, H Park… - Advanced Healthcare …, 2020 - Wiley Online Library
Multi‐cellular spheroids are formed as a 3D structure with dense cell–cell/cell–extracellular
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

X Yuan, L Sun, R Jeske, D Nkosi… - Journal of …, 2022 - Wiley Online Library
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …

Living and injectable porous hydrogel microsphere with paracrine activity for cartilage regeneration

X Li, X Li, J Yang, J Lin, Y Zhu, X Xu, W Cui - Small, 2023 - Wiley Online Library
Paracrine is an important mechanism in mesenchymal stem cells (MSCs) that promotes
tissue regeneration. However, anoikis is attributed to unsuitable adhesion microenvironment …

Spheroid culture of mesenchymal stem cells

Z Cesarz, K Tamama - Stem cells international, 2016 - Wiley Online Library
Compared with traditional 2D adherent cell culture, 3D spheroidal cell aggregates, or
spheroids, are regarded as more physiological, and this technique has been exploited in the …

Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs

N Di Caprio, JA Burdick - Acta biomaterialia, 2023 - Elsevier
Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …

Combination of 3D printing and electrospinning techniques for biofabrication

DL Yang, F Faraz, JX Wang… - Advanced Materials …, 2022 - Wiley Online Library
This review presents the different combination methods of 3D printing and electrospinning
processes and discusses the advantages of each method. Also, the applications of products …

Stromal cells and stem cells in clinical bone regeneration

WL Grayson, BA Bunnell, E Martin, T Frazier… - Nature Reviews …, 2015 - nature.com
Stem-cell-mediated bone repair has been used in clinical trials for the regeneration of large
craniomaxillofacial defects, to slow the process of bone degeneration in patients with …

MSC spheroids-loaded collagen hydrogels simultaneously promote neuronal differentiation and suppress inflammatory reaction through PI3K-Akt signaling pathway

J He, N Zhang, Y Zhu, R Jin, F Wu - Biomaterials, 2021 - Elsevier
It is critical for the clinical success to take the anti-inflammatory function into consideration
when integrating the neurogenesis into the nerve repair materials. To this aim, we prepared …

[HTML][HTML] Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications

D Kouroupis, D Correa - Frontiers in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …