The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

Following heat stress, the mammalian intestinal epithelial cells respond by producing heat
shock proteins that confer protection under stressful conditions, which would otherwise lead …

Skeletal muscle is an integral tissue system that plays a crucial role in the physical function
of all vertebrates and is a key target for maintaining or improving health and performance …

Thermal stress has been considered to be among the most important determinants of
organismal distribution in the rocky intertidal zone. Yet our understanding of how body …

The heat stress response is associated with several beneficial adaptations that promote cell
health and survival. Specifically, in vitro and animal investigations suggest that repeated …

Epidermal growth factor receptor (EGFR) signaling in the mammalian hypothalamus is
important in the circadian regulation of activity. We have examined the role of this pathway in …

Cypermethrin (CYP), an insecticide, has deleterious effects on male reproductive function.
The objective was to identify whether the effects of beta-CYP on male reproductive organs …

Background The use of cyclophosphamide (CP) as a chemotherapeutic agent is limited by
its major complication haemorrhagic cystitis (HC). Finding preventive, safe, and efficient …

Hyperthermia can cause brain damage and also exacerbate the brain damage produced by
stroke and amphetamines. The developing brain is especially sensitive to hyperthermia. The …

Angiogenesis crucially contributes to various diseases, such as cancer and diabetic
retinopathy. Hence, anti-angiogenic therapy is considered as a powerful strategy against …