[HTML][HTML] Peripheral and central immune system crosstalk in Alzheimer disease—a research prospectus

BM Bettcher, MG Tansey, G Dorothée… - Nature Reviews …, 2021 - nature.com
Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

[HTML][HTML] IL-1β, IL-6, TNF-α and CRP in elderly patients with depression or Alzheimer's disease: systematic review and meta-analysis

A Ng, WW Tam, MW Zhang, CS Ho, SF Husain… - Scientific reports, 2018 - nature.com
We carried out systematic review and meta-analysis to evaluate whether peripheral levels of
pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor …

[HTML][HTML] Effect of high-fat diets on oxidative stress, cellular inflammatory response and cognitive function

BL Tan, ME Norhaizan - Nutrients, 2019 - mdpi.com
Cognitive dysfunction is linked to chronic low-grade inflammatory stress that contributes to
cell-mediated immunity in creating an oxidative environment. Food is a vitally important …

[HTML][HTML] Diet and inflammation in cognitive ageing and Alzheimer's disease

AM McGrattan, B McGuinness, MC McKinley… - Current nutrition …, 2019 - Springer
Abstract Purpose of Review Nutrition is known to modulate the immune system and may
alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer's disease …

[HTML][HTML] Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

S Pugazhenthi, L Qin, PH Reddy - … acta (BBA)-molecular basis of disease, 2017 - Elsevier
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …

Peripheral inflammatory markers in Alzheimer's disease: a systematic review and meta-analysis of 175 studies

KSP Lai, CS Liu, A Rau, KL Lanctôt… - Journal of Neurology …, 2017 - jnnp.bmj.com
Objectives Increasing evidence suggests that inflammation is involved in Alzheimer's
disease (AD) pathology. This study quantitatively summarised the data on peripheral …

[HTML][HTML] TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

RY Li, Q Qin, HC Yang, YY Wang, YX Mi, YS Yin… - Molecular …, 2022 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Risk factors associated with the onset and progression of Alzheimer's disease: A systematic review of the evidence

M Hersi, B Irvine, P Gupta, J Gomes, N Birkett… - Neurotoxicology, 2017 - Elsevier
A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …

Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis

SC Larsson, M Traylor, R Malik, M Dichgans… - bmj, 2017 - bmj.com
Objective To determine which potentially modifiable risk factors, including socioeconomic,
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …

Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies

K Deckers, MPJ van Boxtel… - … journal of geriatric …, 2015 - Wiley Online Library
Objective Dementia has a multifactorial etiology, but the importance of individual health and
lifestyle related risk factors is often uncertain or based on few studies. The goal of this paper …