Checking NEKs: overcoming a bottleneck in human diseases
A Peres de Oliveira, L Kazuo Issayama… - Molecules, 2020 - mdpi.com
In previous years, several kinases, such as phosphoinositide 3-kinase (PI3K), mammalian
target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been …
target of rapamycin (mTOR), and extracellular-signal-regulated kinase (ERK), have been …
On broken Ne (c) ks and broken DNA: the role of human NEKs in the DNA damage response
ICB Pavan, A Peres de Oliveira, PRF Dias, FL Basei… - Cells, 2021 - mdpi.com
NIMA-related kinases, or NEKs, are a family of Ser/Thr protein kinases involved in cell cycle
and mitosis, centrosome disjunction, primary cilia functions, and DNA damage responses …
and mitosis, centrosome disjunction, primary cilia functions, and DNA damage responses …
Revisiting protein kinase–substrate interactions: Toward therapeutic development
PSL de Oliveira, FAN Ferraz, DA Pena, DT Pramio… - Science …, 2016 - science.org
Despite the efforts of pharmaceutical companies to develop specific kinase modulators, few
drugs targeting kinases have been completely successful in the clinic. This is primarily due …
drugs targeting kinases have been completely successful in the clinic. This is primarily due …
NEK7: a potential therapy target for NLRP3-related diseases
G Liu, X Chen, Q Wang, L Yuan - Bioscience trends, 2020 - jstage.jst.go.jp
NLRP3 inflammasome plays an essential role in innate immunity, yet the activation
mechanism of NLRP3 inflammasome is not clear. In human or animal models, inappropriate …
mechanism of NLRP3 inflammasome is not clear. In human or animal models, inappropriate …
Conserved NIMA kinases regulate multiple steps of endocytic trafficking
Human NIMA-related kinases have primarily been studied for their roles in cell cycle
progression (NEK1/2/6/7/9), checkpoint–DNA-damage control (NEK1/2/4/5/10/11), and …
progression (NEK1/2/6/7/9), checkpoint–DNA-damage control (NEK1/2/4/5/10/11), and …
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs
B Van de Kooij, P Creixell, A van Vlimmeren… - Elife, 2019 - elifesciences.org
Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few
substrates are known. We systematically determined the phosphorylation-site motifs for the …
substrates are known. We systematically determined the phosphorylation-site motifs for the …
Physiological and pathological roles of mammalian NEK7
Z Sun, W Gong, Y Zhang, Z Jia - Frontiers in physiology, 2020 - frontiersin.org
NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and
physiological roles of NEK7 have been widely reported in many studies. To date, the major …
physiological roles of NEK7 have been widely reported in many studies. To date, the major …
Identification of NEK7 inhibitors: structure based virtual screening, molecular docking, density functional theory calculations and molecular dynamics simulations
NEK7 is a NIMA related-protein kinase that plays a crucial role in spindle assembly and cell
division. Dysregulation of NEK7 protein leads to development and progression of different …
division. Dysregulation of NEK7 protein leads to development and progression of different …
GBS Mapping and Analysis of Genes Conserved between Gossypium tomentosum and Gossypium hirsutum Cotton Cultivars that Respond to Drought Stress at the Seedling Stage of the …
RO Magwanga, P Lu, JN Kirungu, L Diouf… - International journal of …, 2018 - mdpi.com
Cotton production is on the decline due to ever-changing environmental conditions. Drought
and salinity stress contribute to over 30% of total loss in cotton production, the situation has …
and salinity stress contribute to over 30% of total loss in cotton production, the situation has …
Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
T Haq, MW Richards, SG Burgess, P Gallego… - Nature …, 2015 - nature.com
Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7
and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated …
and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated …