A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread
musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a …

Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell
types are likely involved in this disease. We recently generated rNLS8 mice in which human …

Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Numerous preclinical studies support the role of spinal neuroimmune activation in the
pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)-or macrophage …

Abstract Gulf War Illness (GWI) is a chronic disorder affecting approximately 30% of the
veterans who served in the 1991 Gulf War. It is characterised by a constellation of symptoms …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which leads
to death in a median time of 2–3 years. Inflammation has been claimed important to the ALS …

Objective The neurodegenerative disease, amyotrophic lateral sclerosis (ALS), is a
heterogeneous clinical syndrome involving multiple molecular pathways. The development …