COPD is a heterogeneous disorder that shows diverse clinical presentations (phenotypes
and “treatable traits”) and biological mechanisms (endotypes). This heterogeneity implies …

The clinical presentation of chronic obstructive pulmonary disease (COPD) is highly
heterogeneous. Attempts have been made to define subpopulations of patients who share …

Sarcopenia is a major comorbidity in chronic obstructive pulmonary (COPD). Whether
deficient muscle repair mechanisms and regeneration exist in the vastus lateralis (VL) of …

We hypothesized that treatment with pharmacological agents known to increase sirtuin-1
activity (resveratrol and curcumin) may enhance muscle regeneration. In limb muscles of …

Impaired muscle strength and mass (sarcopenia) are common in patients with respiratory
cachexia, namely chronic obstructive pulmonary disease (COPD) and in lung cancer (LC) …

Background Some patients with COPD suffer frequent exacerbations (FE). We hypothesised
that their systemic proteomic profile would be different from that of non-frequent …

Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic
obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can …

We hypothesized that curcumin may mitigate muscle protein degradation and loss through
attenuation of proteolytic activity in limb muscles of mice exposed to reloading (7dR) …

Respiratory muscle dysfunction is common in patients with chronic obstructive pulmonary
disease (COPD). Chronic contractile activity induces endoplasmic reticulum (ER) stress and …

Although Chronic Obstructive Pulmonary Disease (COPD) is highly prevalent, it is often
underdiagnosed. One of the main characteristics of this heterogeneous disease is the …