Nitric oxide (NO) has diverse physiological and pathophysiological effects. The roles of NO
in the renal and cardiac dysfunction found in cirrhosis are reviewed. In the kidneys of …

BACKGROUND: Reactive oxygen species (ROS), including superoxide anion radical (O2−),
plays an important role in carcinogenesis. The human body has developed different …

BACKGROUND There is considerable evidence indicating that the severity of hepatic
damage in individuals with cholestatic liver disease is causally associated with the extent of …

We examined whether melatonin exerts a therapeutic effect on cholestatic liver injury in rats
treated with bile duct ligation (BDL). Cholestatic liver injury was induced in male Wistar rats …

Excessive production of hydroxyl radicals in blood and liver has previously been
demonstrated by us in rats with obstructive jaundice induced by common bile duct ligation …

Background/Aims: Our aim was to investigate whether the antioxidant quercetin might
protect against liver injury in chronically biliary obstructed rats. Methods: Secondary biliary …

Lipid peroxidation and antioxidative mechanisms were investigated in liver mitochondria
from bile duct ligated rats (BDL rats) and correlated with the activity of enzyme complexes of …

BACKGROUND: Reactive oxygen species and oxidative stress are implicated in hepatic
stellate cell activation and liver fibrosis, which are initiated by recruitment of inflammatory …

The role of reactive oxygen species in liver fibrogenesis is not yet clarified. The aim of this
study was to investigate oxidative-stress-related changes in cirrhotic rats. Cirrhosis was …

Acute cholestasis-induced renal failure: Effects of antioxidants and ligands for the
thromboxane A 2 receptor. Background Acute biliary obstruction is associated with the …