Revealing lncRNA structures and interactions by sequencing-based approaches

X Qian, J Zhao, PY Yeung, QC Zhang… - Trends in biochemical …, 2019 - cell.com
Long noncoding RNAs (lncRNAs) have emerged as significant players in almost every level
of gene function and regulation. Thus, characterizing the structures and interactions of …

Evolution to the rescue: using comparative genomics to understand long non-coding RNAs

I Ulitsky - Nature Reviews Genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) have emerged in recent years as major players in a
multitude of pathways across species, but it remains challenging to understand which of …

RNA-mediated epigenetic regulation of gene expression

D Holoch, D Moazed - Nature Reviews Genetics, 2015 - nature.com
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

Technological developments in lncRNA biology

S Jathar, V Kumar, J Srivastava, V Tripathi - Long Non Coding RNA …, 2017 - Springer
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …

[HTML][HTML] lincRNAs: genomics, evolution, and mechanisms

I Ulitsky, DP Bartel - Cell, 2013 - cell.com
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …

On the classification of long non-coding RNAs

L Ma, VB Bajic, Z Zhang - RNA biology, 2013 - Taylor & Francis
Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide
variety of important biological processes. To make easier interpretation of lncRNA …

RNA structure probing uncovers RNA structure-dependent biological functions

XW Wang, CX Liu, LL Chen, QC Zhang - Nature chemical biology, 2021 - nature.com
RNA molecules fold into complex structures that enable their diverse functions in cells.
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …

Genome regulation by long noncoding RNAs

JL Rinn, HY Chang - Annual review of biochemistry, 2012 - annualreviews.org
The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …

[HTML][HTML] RNA duplex map in living cells reveals higher-order transcriptome structure

Z Lu, QC Zhang, B Lee, RA Flynn, MA Smith… - Cell, 2016 - cell.com
RNA has the intrinsic property to base pair, forming complex structures fundamental to its
diverse functions. Here, we develop PARIS, a method based on reversible psoralen …

Evolutionary conservation of long non-coding RNAs; sequence, structure, function

P Johnsson, L Lipovich, D Grandér… - Biochimica et Biophysica …, 2014 - Elsevier
Background Recent advances in genomewide studies have revealed the abundance of long
non-coding RNAs (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has …