Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Primary cilia are hair-like organelles and play crucial roles in vertebrate development,
organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory …

Polycystic kidney disease (PKD) is a leading cause of ESRD worldwide. In PKD, excessive
cell proliferation and fluid secretion, pathogenic interactions of mutated epithelial cells with …

Mechanosensitive ion channels are gated directly by physical stimuli and transduce these
stimuli into electrical signals. Several criteria must apply for a channel to be considered …

WNT ligands induce Ca2+ signalling on target cells. PKD1 (polycystin 1) is considered an
orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2) …

Rationale: Cardiac muscle adapts to increase workload by altering cardiomyocyte size and
function resulting in cardiac hypertrophy. G protein–coupled receptor signaling is known to …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic
kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia …

TRP channels constitute a large superfamily of cation channel forming proteins, all related to
the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 …