[HTML][HTML] Regulatory mechanism of MicroRNA expression in cancer

Z Ali Syeda, SSS Langden, C Munkhzul, M Lee… - International journal of …, 2020 - mdpi.com
Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …

[HTML][HTML] MicroRNA let-7 and viral infections: focus on mechanisms of action

A Letafati, S Najafi, M Mottahedi, M Karimzadeh… - Cellular & Molecular …, 2022 - Springer
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical
cellular processes, a number of which are involved in host defense mechanisms. In …

DIANA-miTED: a microRNA tissue expression database

I Kavakiotis, A Alexiou, S Tastsoglou… - Nucleic Acids …, 2022 - academic.oup.com
Abstract microRNAs (miRNAs) are short (∼ 23nt) single-stranded non-coding RNAs that act
as potent post-transcriptional gene expression regulators. Information about miRNA …

miRmine: a database of human miRNA expression profiles

B Panwar, GS Omenn, Y Guan - Bioinformatics, 2017 - academic.oup.com
Motivation MicroRNAs (miRNAs) are small non-coding RNAs that are involved in post-
transcriptional regulation of gene expression. In this high-throughput sequencing era, a …

A microRNA-inducible CRISPR–Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool

XW Wang, LF Hu, J Hao, LQ Liao, YT Chiu, M Shi… - Nature cell …, 2019 - nature.com
Abstract microRNAs (miRNAs) are small noncoding RNAs that play important regulatory
roles in plants, animals and viruses. Measuring miRNA activity in vivo remains a big …

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

Y Wang, X Xu, S Yu, KJ Jeong, Z Zhou, L Han… - Genome …, 2017 - genome.cshlp.org
RNA editing, a widespread post-transcriptional mechanism, has emerged as a new player in
cancer biology. Recent studies have reported key roles for individual miRNA editing events …

ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion

V Cesarini, DA Silvestris, V Tassinari… - Nucleic acids …, 2018 - academic.oup.com
Recent studies have reported the emerging role of microRNAs (miRNAs) in human cancers.
We systematically characterized miRNA expression and editing in the human brain, which …

An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools

J Gong, C Liu, W Liu, Y Wu, Z Ma, H Chen, AY Guo - Database, 2015 - academic.oup.com
MicroRNAs (miRNAs) are key regulators of gene expression involved in a broad range of
biological processes. MiRNASNP aims to provide single nucleotide polymorphisms (SNPs) …

Human cancer tissues exhibit reduced A-to-I editing of miRNAs coupled with elevated editing of their targets

Y Pinto, I Buchumenski, EY Levanon… - Nucleic Acids …, 2018 - academic.oup.com
Abstract A-to-I RNA editing is an important post-transcriptional modification, known to be
altered in tumors. It targets dozens of sites within miRNAs, some of which impact miRNA …

[HTML][HTML] A-to-I–edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis

X Xu, Y Wang, K Mojumdar, Z Zhou… - The Journal of …, 2019 - Am Soc Clin Investig
Both miRNAs and A-to-I RNA editing, a widespread nucleotide modification mechanism,
have recently emerged as key players in cancer pathophysiology. However, the functional …