Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
G Musso, M Cassader, R Gambino - Nature reviews Drug discovery, 2016 - nature.com
Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) …
[HTML][HTML] Annexin animal models—from fundamental principles to translational research
Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …
research. Traits that are only associated with advanced developmental stages can now be …
[PDF][PDF] Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease
The role of inflammation in obesity-related pathologies is well established. We investigated
the therapeutic potential of LipoxinA 4 (LXA 4: 5 (S), 6 (R), 15 (S)-trihydroxy-7E, 9E, 11Z …
the therapeutic potential of LipoxinA 4 (LXA 4: 5 (S), 6 (R), 15 (S)-trihydroxy-7E, 9E, 11Z …
The attenuation of diabetic nephropathy by annexin A1 via regulation of lipid metabolism through the AMPK/PPARα/CPT1b pathway
L Wu, C Liu, DY Chang, R Zhan, M Zhao… - Diabetes, 2021 - Am Diabetes Assoc
Inflammation and abnormal metabolism play important roles in the pathogenesis of diabetic
nephropathy (DN). Annexin A1 (ANXA1) contributes to inflammation resolution and …
nephropathy (DN). Annexin A1 (ANXA1) contributes to inflammation resolution and …
[HTML][HTML] Annexins in translational research: hidden treasures to be found
S Schloer, D Pajonczyk, U Rescher - International journal of molecular …, 2018 - mdpi.com
The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca2+) and
phospholipid binding protein family which share a high structural homology. In keeping with …
phospholipid binding protein family which share a high structural homology. In keeping with …
[PDF][PDF] Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice
Annexin A1 (AnxA1) is an effector of the resolution of inflammation and is highly effective in
terminating acute inflammatory responses. However, its role in chronic settings is less …
terminating acute inflammatory responses. However, its role in chronic settings is less …
[HTML][HTML] Annexins–insights from knockout mice
Annexins are a highly conserved protein family that bind to phospholipids in a calcium (Ca
2+)–dependent manner. Studies with purified annexins, as well as overexpression and …
2+)–dependent manner. Studies with purified annexins, as well as overexpression and …
[HTML][HTML] The crosstalk of ABCA1 and ANXA1: A potential mechanism for protection against atherosclerosis
X Shen, S Zhang, Z Guo, D Xing, W Chen - Molecular Medicine, 2020 - Springer
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic
inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol …
inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol …
The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution
JP Vago, LP Tavares, CC Garcia, KM Lima… - The Journal of …, 2015 - journals.aai.org
Glucocorticoid (GC)-induced leucine zipper (GILZ) has been shown to mediate or mimic
several actions of GC. This study assessed the role of GILZ in self-resolving and GC-induced …
several actions of GC. This study assessed the role of GILZ in self-resolving and GC-induced …
[PDF][PDF] Dopamine signaling in the suprachiasmatic nucleus enables weight gain associated with hedonic feeding
The widespread availability of energy-dense, rewarding foods is correlated with the
increased incidence of obesity across the globe. Overeating during mealtimes and …
increased incidence of obesity across the globe. Overeating during mealtimes and …