The circadian neurobiology of reward

I Olejniczak, K Begemann, I Wilhelm… - Acta …, 2023 - Wiley Online Library
Circadian clocks are important regulators of physiology and behavior. In the brain, circadian
clocks have been described in many centers of the central reward system. They affect …

Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli

P Berbegal-Sáez, I Gallego-Landin, J Macía… - Open …, 2024 - royalsocietypublishing.org
Maintaining proper circadian rhythms is essential for coordinating biological functions in
mammals. This study investigates the effects of daily arrhythmicity using Bmal1-knockout …

Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice

Q Wu, Q Ren, X Wang, H Bai, D Tian… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Disturbances in the circadian rhythm are positively correlated with the processes of
aging and related neurodegenerative diseases, which are also associated with brain iron …

The circadian system: A neglected player in neurodevelopmental disorders

AA Bouteldja, D Penichet, LK Srivastava… - European Journal of …, 2024 - Wiley Online Library
Patients with neurodevelopmental disorders, such as autism spectrum disorder, often
display abnormal circadian rhythms. The role of the circadian system in these disorders has …

Propofol improves sleep deprivation‐induced sleep structural and cognitive deficits via upregulating the BMAL1 expression and suppressing microglial M1 …

H Liu, C Yang, X Wang, B Yu, Y Han… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Sleep deprivation (SD) is a growing global health problem with many
deleterious effects, such as cognitive impairment. Microglia activation‐induced …

[HTML][HTML] The FAAH inhibitor URB597 reduces cocaine intake during conditioned punishment and mitigates cocaine seeking during withdrawal

L Alegre-Zurano, A García-Baos… - Biomedicine & …, 2023 - Elsevier
The endocannabinoid system is prominently implicated in the control of cocaine
reinforcement due to its relevant role in synaptic plasticity and neurotransmitter modulation …

Sex differences in the effects of N‐ethylpentylone in young CD1 mice: Insights on behaviour, thermoregulation and early gene expression

M Espinosa‐Velasco, A Castro‐Zavala… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose New psychoactive substances such as N‐ethylpentylone
(NEP) are continuously emerging in the illicit drug market, and knowledge of their effects …

[HTML][HTML] BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation

J Xu, C Li, R Fan, J Yin, L Xie, X Peng, J Tao… - Cell Communication and …, 2025 - Springer
Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM).
However, the mechanisms underlying the development of cognitive dysfunction in …

Bmal1 regulates female reproduction in mice via the hypothalamic–pituitary–ovarian axis

A Zhang, S Li, L Huang, Y Jiang, Y Chen… - The FASEB …, 2024 - Wiley Online Library
The hypothalamic–pituitary–gonadal axis (HPG) is the key neuroendocrine axis involved in
reproductive regulation. Brain and muscle ARNT‐like protein 1 (Bmal1) participates in …

The role of circadian clock gene Arntl in the winter depression-like behavior in melatonin-proficient female CBA/N mice

L Ren, K Okimura, A Ishikawa, N Kon, S Shimba… - Biochemical and …, 2024 - Elsevier
Seasonal affective disorder (SAD), also known as winter depression, is a subtype of
depression typically manifesting in winter. Typical symptoms of SAD, such as an increased …