Successful solid organ transplantation reflects meticulous attention to the details of
immunosuppression, balancing risks for graft rejection against risks for infection. The “net …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Regulatory T cells (Tregs) make major contributions to immune homeostasis. Because Treg
dysfunction can lead to both allo-and autoimmunity, there is interest in correcting these …

The lymph node (LN) is the primary site of alloimmunity activation and regulation during
transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the …

Background The demand for donated human hearts far exceeds the number available.
Xenotransplantation of genetically modified porcine organs provides an alternative. In 2000 …

The search for alternatives to allotransplants is driven by the shortage of corneal donors and
is demanding because of the limitations of the alternatives. Indeed, current progress in …

Heart transplantation is the only long-lasting lifesaving option for patients with terminal
cardiac failure. The number of available human organs is however far below the actual …

There is an urgent need for therapeutic interventions for desensitization and antibody-
mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific …

Strong xenorejection limits the clinical application of porcine islet transplantation in type 1
diabetes. Targeting T cell-mediated rejection is one of the main approaches to improve long …

In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human
decedents did not show evidence of acute-onset cellular-or antibody-mediated rejection …