Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …
synaptic transmission, are widely distributed throughout the central nervous system, and …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
NMDA receptor structures reveal subunit arrangement and pore architecture
Abstract N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors,
requiring binding of glycine and glutamate in combination with the relief of voltage …
requiring binding of glycine and glutamate in combination with the relief of voltage …
[PDF][PDF] Structure, function, and pharmacology of NMDA receptor channels
V Vyklicky, M Korinek, T Smejkalova, A Balik… - Physiological …, 2014 - researchgate.net
Structure, Function, and Pharmacology of NMDA Receptor Channels Page 1
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2014 …
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2014 …
Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors
NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and
GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor …
GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor …
Unravelling and exploiting astrocyte dysfunction in Huntington's disease
BS Khakh, V Beaumont, R Cachope… - Trends in …, 2017 - cell.com
Astrocytes are abundant within mature neural circuits and are involved in brain disorders.
Here, we summarize our current understanding of astrocytes and Huntington's disease (HD) …
Here, we summarize our current understanding of astrocytes and Huntington's disease (HD) …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
[HTML][HTML] Influence of GluN2 subunit identity on NMDA receptor function
N-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …